Metabolism of Bile Acids. XIV. Sarcosine Conjugated Bile Acids
نویسندگان
چکیده
منابع مشابه
Metabolism of steroid and amino acid moieties of conjugated bile acids in man. II. Glycine-conjugated dihydroxy bile acids.
Chenodeoxycholyl-2,4-(3)H-glycine-1-(14)C and deoxycholyl-2,4-(3)H-glycine-1-(14)C were synthesized and administered orally to 10 healthy subjects. Distribution of radioactivity among bile acids and specific activity of steroid and amino acid moieties were determined in bile samples. (3)H and (14)C were measured in feces. (14)C in breath was calculated from interval (14)CO(2) specific activity ...
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A method has been developed and validated for the determination of the six major conjugated bile acids, cholesterol, and total phospholipids in bile of human subjects previously injected with 4-(14)C-cholesterol. The procedure is designed for use with 5-10 ml of duodenal or T-tube bile and eliminates difficulties associated with existing methods for bile acid determination, in particular the re...
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In 1916 Wieland and Sorge (1) first described the formation of addition compounds of desoxycholic acid with fatty acids, and suggested the possible importance of this “choleic acid principle” in furthering the absorption of fatty acids and other substances from the intestinal canal. In human bile, however, desoxycholic acid is united with glycine and taurine; hence it is of considerable importa...
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The dissociation constants for the carboxyl group of a series of glycine (N-acyl)-conjugated and unconjugated bile acids were determined by potentiometric titration using dimethylsulfoxide-water and methanol-water mixtures of varying proportions. The pKa values in water were calculated by extrapolating the experimental values determined in different mole fractions of the organic solvent mixture...
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Bile acids, the metabolites of cholesterol, are signaling molecules that play critical role in many physiological functions. They undergo enterohepatic circulation through various transporters expressed in intestine and liver. Human organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of bile acids such as taurocholic acid. However, the transport propertie...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1984
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.104.5_466